![]() Our data suggest that BDNF-Rac1/RhoA pathway may be involved in attenuation of CUMS-induced behavioral and neuronal damage by Paeonol that may represent a novel therapeutic agent for depression.īDNF Cofilin1 Dendritic spine Depression Paeonol. The induction of CUMS downregulated BDNF levels and upregulated Rac1/RhoA levels however, the tendency of these was inhibited by treatment with Paeonol. Simultaneously, administration of Paeonol deterred CUMS-induced cofilin1 activation that is essential for remolding of dendritic spines. However, CUMS or Paeonol treatment does not selectively affect dendritic spine types. After Paeonol treatment for 4 weeks, the dendritic length and complexity and the density of dendritic spines markedly increased in the hippocampal CA1 and the dentate gyrus (DG). Paeonol attenuated CUMS-induced depression-like behaviors, which were accompanied by hippocampal neuronal morphological alterations. BDNF signaling pathway-related molecules was determined by Western blotting. Neuronal morphology in hippocampal CA1 and DG was assessed using ImageJ's Sholl plugin and RESCONSTRUCT software. Using CUMS rat model, the antidepressant-like effect of Paeonol was validated via depression-related behavioral tests. ![]() The present study investigated the effect of Paeonol on hippocampal neuronal morphology and its possible signaling pathways in chronic unpredictable mild stress (CUMS) rat model. However, it is unclear what signaling pathways contribute to improve MDD. Recent studies have reported its antidepressant effects. ![]() ![]() Paeonol is a kind of polyphenols natural product with a variety of therapeutic effects. She has since completed her studies as a sports psychologist, and has returned to the Chinese mainland to work for the national table tennis team.Increasing evidence has suggested that major depressive disorder (MDD) is highly associated with brain-derived neurotrophic factor (BDNF) levels, dendrites atrophy, and loss of dendritic spines, especially in emotion-associated brain regions including the hippocampus. Chen, also a medallist at the 1997 (mixed doubles) and 2000 Worlds (team), retired after the Sydney Games. In Sydney, 2000, she would again medal, earning a bronze to gain a full collection of Olympic medals. Her research interests are in the field of asset pricing and her work thus far has focused on how information is incorporated into asset prices under a dynamic setting. Chen then rallied to tie the game at 2-2, but eventually lost 3-2. candidate in finance in the Department of Finance and Management Science. The match was interrupted at 2-0 for Deng, as a Taiwanese supporter carrying the national flag – not allowed by IOC rules as the nation competes as Chinese Taipei – was removed by police. There she played the defending champion, Deng Yaping. In Atlanta, she competed for her new nation, and defeated favorite Qiao Hong to reach the final. She won her first international prize at the 1993 Worlds, earning a silver. In 1991, she started training in Taiwan, and settled there the following year. It would be her final medals competing for the People’s Republic. Chen also won four medals at the 1989 World Championships, bronze in the singles, silver in the doubles, bronze in the mixed doubles, and gold with the Chinese team. She picked up a second medal in the doubles, winning silver with Jiao Zhimin, the individual bronze medallist. ![]() She waltzed through the field, not losing a single game until the final, in which she defeated fellow Chinese Li Huifen, 3-2. When table tennis débuted at the Olympics in 1988, the Chinese did not field their highest ranked players, giving Chen a chance at a medal. Chen Jing is the only Olympian to have won Olympic medals for both the People’s Republic of China and the Republic of China, which competes as Chinese Taipei at the Olympics. Xiu-Ling Zhu 1 2, Jing-Jing Chen 1, Fei Han 1, Chuan Pan 1, Ting-Ting Zhuang 1, Ya-Fei Cai 1, Ya-Ping Lu 3 Affiliations 1 College of Life Science, Anhui Normal University, Wuhu, 241000, China. ![]()
0 Comments
Leave a Reply. |
Details
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |